An evolutionary perspective on zinc uptake by human fungal pathogens

DW is supported by a Sir Henry Dale Fellowship jointly funded by the Wellcome Trust and the Royal Society (Grant Number 102549/Z/13/Z).Peer reviewedPublisher PD

Essential metals at the host-pathogen interface : nutritional immunity and micronutrient assimilation by human fungal pathogens

AC and DW are supported by a Sir Henry Dale Fellowship jointly funded by the Wellcome Trust and the Royal Society (Grant Number 102549/Z/13/Z).Peer reviewedPublisher PD

Chapter 4 'Where to draw the line?' Mary Warnock, embryos and moral expertise

Recent decades have witnessed profound shifts in the politics of medicine and the biological sciences. Members of several professions, including philosophers, lawyers and social scientists, now discuss and help regulate issues that were once left to doctors and scientists, in a form of outside involvement known as ‘bioethics’. The making of British bioethics provides the first in-depth study of the growing demand for this outside involvement in Britain, where bioethicists have become renowned and influential ‘ethics experts’. The book moves beyond existing histories, which often claim that bioethics arose in response to questions surrounding new procedures such as in vitro fertilisation. It shows instead that British bioethics emerged thanks to a dynamic interplay between changing sociopolitical concerns and the aims of specific professional groups and individuals. Highlighting this interplay has important implications for our understanding of how issues such as embryo experiments, animal research and assisted dying became high profile ‘bioethical’ concerns in late twentieth century Britain. And it also helps us appreciate how various individuals and groups intervened in and helped create the demand for bioethics, playing a major role in their transformation into ‘ethics experts’. The making of British bioethics draws on a wide range of materials, including government archives, popular sources, professional journals, and original interviews with bioethicists and politicians. It is clearly written and will appeal to historians of medicine and science, general historians, bioethicists, and anyone interested in what the emergence of bioethics means for our notions of health, illness and morality

A Troubled Past? Reassessing Ethics in the History of Tissue Culture

Recent books, articles and plays about the ‘immortal’ HeLa cell line have prompted renewed interest in the history of tissue culture methods that were first employed in 1907 and became common experimental tools during the twentieth century. Many of these sources claim tissue cultures like HeLa had a “troubled past” because medical researchers did not seek informed consent before using tissues in research, contravening a long held desire for self-determination on the part of patients and the public. In this article, I argue these claims are unfair and misleading. No professional guidelines required informed consent for tissue culture during the early and mid twentieth century, and popular sources expressed no concern at the widespread use of human tissues in research. When calls for informed consent did emerge in the 1970s and 1980s, moreover, they reflected specific political changes and often emanated from medical researchers themselves. I conclude by arguing that more balanced histories of tissue culture can make a decisive contribution to public debates today: by refuting a false dichotomy between science and its publics, and showing how ethical concepts such as informed consent arise from a historically specific engagement between professional and social groups

The Making of British Bioethics

Recent decades have witnessed profound shifts in the politics of medicine and the biological sciences. Members of several professions, including philosophers, lawyers and social scientists, now discuss and help regulate issues that were once left to doctors and scientists, in a form of outside involvement known as ‘bioethics’. The making of British bioethics provides the first in-depth study of the growing demand for this outside involvement in Britain, where bioethicists have become renowned and influential ‘ethics experts’. The book moves beyond existing histories, which often claim that bioethics arose in response to questions surrounding new procedures such as in vitro fertilisation. It shows instead that British bioethics emerged thanks to a dynamic interplay between changing sociopolitical concerns and the aims of specific professional groups and individuals. Highlighting this interplay has important implications for our understanding of how issues such as embryo experiments, animal research and assisted dying became high profile ‘bioethical’ concerns in late twentieth century Britain. And it also helps us appreciate how various individuals and groups intervened in and helped create the demand for bioethics, playing a major role in their transformation into ‘ethics experts’. The making of British bioethics draws on a wide range of materials, including government archives, popular sources, professional journals, and original interviews with bioethicists and politicians. It is clearly written and will appeal to historians of medicine and science, general historians, bioethicists, and anyone interested in what the emergence of bioethics means for our notions of health, illness and morality

Online Optimisation of Casualty Processing in Major Incident Response

Recent emergency response operations to Mass Casualty Incidents (MCIs) have been criticised for a lack of coordination, implying that there is clear potential for response operations to be improved and for corresponding benefits in terms of the health and well-being of those affected by such incidents. In this thesis, the use of mathematical modelling, and in particular optimisation, is considered as a means with which to help improve the coordination of MCI response. Upon reviewing the nature of decision making in MCIs and other disaster response operations in practice, this work demonstrates through an in-depth review of the available academic literature that an important problem has yet to be modelled and solved using an optimisation methodology. This thesis involves the development of such a model, identifying an appropriate task scheduling formulation of the decision problem and a number of objective functions corresponding to the goals of the MCI response decision makers. Efficient solution methodologies are developed to allow for solutions to the model, and therefore to the MCI response operation, to be found in a timely manner. Following on from the development of the optimisation model, the dynamic and uncertain nature of the MCI response environment is considered in detail. Highlighting the lack of relevant research considering this important aspect of the problem, the optimisation model is extended to allow for its use in real-time. In order to allow for the utility of the model to be thoroughly examined, a complementary simulation is developed and an interface allowing for its communication with the optimisation model specified. Extensive computational experiments are reported, demonstrating both the danger of developing and applying optimisation models under a set of unrealistic assumptions, and the potential for the model developed in this work to deliver improvements in MCI response operations

Unpacking Assessment: Understanding Teacher Agency in the Creation and Use of Local Assessments

Current research into data use suggests that the intersection of assessment, reform, and public accountability and their impact on teacher practice are under-conceptualized and not well researched, especially when the data are derived from assessments that are locally produced by teachers. This qualitative case study investigates the development and use of local assessments in public schools in order to better understand how the act of creating local assessments and using data derived from local assessments influences teacher practice within the current state accountability policy environment. The conceptual frame and methodology of the study draw from existing literature on data use, teacher agency, as well as sense making theory. In particular, data use literature and sense making theory view teacher practice and teacher agency as situated in social and institutional contexts. Data for this study are derived from a year-long study of small groups of teachers in one suburban New York district who are engaged in professional development to develop and use assessments to inform their practice. The teams were trained through the Performance Assessment Design Initiative (PADI) where they developed learning objectives, rubrics as well as pre- and post-assessments based on state and local standards. The data in the study include assessment materials, non-participant observations, and individual interviews of teachers and team facilitators

Chapter 6 Consolidating the 'ethics industry': a national ethics committee and bioethics during the 1990s

Recent decades have witnessed profound shifts in the politics of medicine and the biological sciences. Members of several professions, including philosophers, lawyers and social scientists, now discuss and help regulate issues that were once left to doctors and scientists, in a form of outside involvement known as ‘bioethics’. The making of British bioethics provides the first in-depth study of the growing demand for this outside involvement in Britain, where bioethicists have become renowned and influential ‘ethics experts’. The book moves beyond existing histories, which often claim that bioethics arose in response to questions surrounding new procedures such as in vitro fertilisation. It shows instead that British bioethics emerged thanks to a dynamic interplay between changing sociopolitical concerns and the aims of specific professional groups and individuals. Highlighting this interplay has important implications for our understanding of how issues such as embryo experiments, animal research and assisted dying became high profile ‘bioethical’ concerns in late twentieth century Britain. And it also helps us appreciate how various individuals and groups intervened in and helped create the demand for bioethics, playing a major role in their transformation into ‘ethics experts’. The making of British bioethics draws on a wide range of materials, including government archives, popular sources, professional journals, and original interviews with bioethicists and politicians. It is clearly written and will appeal to historians of medicine and science, general historians, bioethicists, and anyone interested in what the emergence of bioethics means for our notions of health, illness and morality

Chapter Abbreviations

Recent decades have witnessed profound shifts in the politics of medicine and the biological sciences. Members of several professions, including philosophers, lawyers and social scientists, now discuss and help regulate issues that were once left to doctors and scientists, in a form of outside involvement known as ‘bioethics’. The making of British bioethics provides the first in-depth study of the growing demand for this outside involvement in Britain, where bioethicists have become renowned and influential ‘ethics experts’. The book moves beyond existing histories, which often claim that bioethics arose in response to questions surrounding new procedures such as in vitro fertilisation. It shows instead that British bioethics emerged thanks to a dynamic interplay between changing sociopolitical concerns and the aims of specific professional groups and individuals. Highlighting this interplay has important implications for our understanding of how issues such as embryo experiments, animal research and assisted dying became high profile ‘bioethical’ concerns in late twentieth century Britain. And it also helps us appreciate how various individuals and groups intervened in and helped create the demand for bioethics, playing a major role in their transformation into ‘ethics experts’. The making of British bioethics draws on a wide range of materials, including government archives, popular sources, professional journals, and original interviews with bioethicists and politicians. It is clearly written and will appeal to historians of medicine and science, general historians, bioethicists, and anyone interested in what the emergence of bioethics means for our notions of health, illness and morality